Connor Shaw went 8 of 14 for 107 yards before reinjuring his throwing shoulder as No. 8 South Carolina beat UAB 49-6 on Saturday night.
Shaw left the game after taking a brutal hit just late in the first half. Team officials said the junior aggravated the bruised right shoulder that kept him out of last week's game.
Sophomore Dylan Thompson took over again, throwing a 95-yard touchdown pass to Damiere Byrd that put South Carolina (3-0) up 35-6 midway through the third quarter.
Gamecocks coach Steve Spurrier picked up his 200th college coaching win, joining Virginia Tech's Frank Beamer, Texas' Mack Brown and Nevada's Chris Ault as the only active Division I coaches to reach that mark.
UAB (0-2) gained 267 yards, but was kept out of the end zone.