Kyle Shanahan says George Kittle (knee) will be OUT.
— Matt Barrows (@mattbarrows) September 18, 2020
Kittle appeared to suffer the knee injury on a tackle in Week 1 against Arizona. He did not practice all week, so this isn’t a huge shock.
Even though the Jets are a weaker opponent, Kittle’s absence will be significant for the 49ers. That’s especially true with Deebo Samuel out as well, although rookie Brandon Aiyuk appears poised to make his NFL debut. Veteran tight end Jordan Reed figures to get the most looks in the passing game in Kittle’s absence.