George Kittle struck a reassuring tone after picking up an ankle injury in the San Francisco 49ers’ 48–27 win over the Indianapolis Colts. George Kittle suffered a rough-looking ankle injury in the second quarter of the San Francisco 49ers’ win over the Indianapolis Colts during Monday Night Football.
We all tuned into Monday Night Football for the nostalgia trip. We wanted to see if 44-year-old Philip Rivers could still sling it like it was 2013. But while Rivers occupied the pre-game headlines, it was Brock Purdy who decided to rewrite the history books at Lucas Oil Stadium.
Brock Purdy delivered one of the best performances by a quarterback in the San Francisco 49ers’ history. He threw five total touchdowns as the Niners defeated the Indianapolis Colts 48-27.
Things didn't start out too well for the 49ers defense in their 48-27 win over the Indianapolis Colts on Monday night, but by the time the game was over, there were a few memorable highlights for multiple players on that side of the ball.
All NFL players enter the season with high hopes, but sometimes seasons don't go as hoped. These 20 players have been some of the biggest disappointments early in the 2025 season.
There have been multiple moments over the past several months where the thought of this San Francisco 49ers team being a number one seed in the playoffs would have seemed far-fetched at best, but that's exactly where they are with two games left to play.
INDIANAPOLIS -- The 49ers just beat the Indianapolis Colts 48-27 and won their 11th game of the season. Last season, they lost 11 games. Which means there's something different and special about this team.
The San Francisco 49ers extended their winning streak to five games with a 48-27 victory over the Indianapolis Colts on Monday night, building momentum as they head into the postseason.
Brock Purdy delivered one of the most impressive performances by a quarterback in San Francisco 49ers history during Monday night's win over the Indianapolis Colts.
The San Francisco 49ers improved to 11-4 on the season after a 48-27 Week 16 win over the Indianapolis Colts at Lucas Oil Stadium in Indianapolis, Indiana.
The San Francisco 49ers stormed to a 48-27 victory over the Indianapolis Colts in Week 16. They are now 11-4 for the season and are two wins away from clinching the No.
For years, Thanksgiving belonged to the NFL, but Christmas belonged to the NBA. Occasionally, an NFL game would fall on Christmas, but it was anomalous, even avoided if possible.
San Francisco 49ers left tackle Trent Williams is not contemplating retirement anytime soon. Despite being 37 years old, Williams continues to perform at an elite level and believes he still has plenty of football left in him.
The NFL can be a cold place, and San Francisco 49ers linebacker Dee Winters made sure to remind Indianapolis Colts quarterback Philip Rivers of that on Monday.
Monday Night Football often delivers drama, and for the San Francisco 49ers, the end of the first half against the Indianapolis Colts brought a collective gasp from the Faithful.
The San Francisco 49ers are continuing their strong December run on Monday night, rarely needing their punter while controlling the game against the Indianapolis Colts.
George Kittle and the San Francisco 49ers are looking to make it five wins in a row on Monday night as they battle the Indianapolis Colts in a Week 16 matchup.
Kyle Shanahan’s coaching performance this season may be his most impressive yet, adding to his record of three NFC West titles, four postseason appearances, and two Super Bowl trips since becoming the San Francisco 49ers coach in 2017.
The San Francisco 49ers (11-4) kept pace in the NFC playoff picture with a 48-27 win over the Indianapolis Colts (8-7), whose once-bright season has taken a dark turn.
There are a lot of great coaches in the NFL. But one sticks out to Troy Aikman, the three-time Super Bowl champion and Monday Night Football announcer: Kyle Shanahan.
The 49ers’ edge rush group has received a boost in time for tonight’s game. Yetur Gross-Matos has been activated from injured reserve, per a team announcement.
The San Francisco 49ers announced they have activated DE Yetur Gross-Matos from injured reserve. They also elevated CB Eli Apple and LB Eric Kendricks from the practice squad for Monday night’s game against the Colts. Gross-Matos, 27, is a former second-round pick of the Panthers back in 2020.
The San Francisco 49ers have finally clarified their stance on Jake Tonges, listing him as the third-string tight end on the depth chart. Tonges became a key contributor in the first half of the season, largely due to George Kittle’s hamstring injury suffered in Week 1.
The San Francisco 49ers have been one of the most injured teams thoughout the entire 2025 season. While the team will never get completely healthy, it is significant to note that they will potentially be getting three significant contributors back on the defensive side of the football in Week 16 against the Indianapolis Colts.
The San Francisco 49ers placed wide receiver Brandon Aiyuk on the reserve/left squad list last week, raising significant questions about his future in San Francisco.